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Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H(37)Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an alpha-hydroxybenzyl substituent in the indolizine 1-position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 microg/mL
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Gundersen et al. (2003) studied this question.
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