The electrocyclic reaction is one of the most powerful tools for the construction of complex polycyclic scaffolds in a highly stereocontrolled fashion. In this review, recent advances in its application in the total synthesis of representative natural products are discussed, with the aim of providing a complement to existing reviews. 1 Introduction 2 4π Electrocyclization 2.1 Neutral 4π Electrocyclization 2.2 Cationic 4π Electrocyclization 3 6π Electrocyclization 3.1 All-Carbon 6π Electrocyclization 3.2 Oxa-6π Electrocyclization 3.3 Aza-6π Electrocyclization 3.4 Retro-6π Electrocyclization 4 8π Electrocyclization 5 Conclusion and Outlook
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Bian et al. (2017) studied this question.