Three-month-old male BALB/c mice were injected intraperitoneally with ²²⁶ RaCl₂ at dose levels of 4.5, 6.9, 9.0, and 13.5 μ Ci ²²⁶ Ra/ kg body wt. At the two highest doses, the number of multipotential bone marrow stem cells was severely depressed 8 weeks after the injection. By 30 weeks no depression was observed compared to controls. The number of peripheral red blood cells was never altered, while the number of white blood cells was slightly depressed after 8 weeks of contamination. Mice fed every other week with standard pellets and on alternate weeks with a diet containing 6% Na-alginate (first given 12 days after the injection of ²²⁶ RaCl₂ ) showed a significant reduction of stem-cell depression 8 and 12 weeks after contamination in three of the six treatment groups with manifest radiation effects on the stem cells.
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Schoeters et al. (1980) studied this question.
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