An Efficient and General Method for the Synthesis of α,ω‐Difunctional Reduced Polypropionates by Zr‐Catalyzed Asymmetric Carboalumination: Synthesis of the Scyphostatin Side Chain

A decrease in the number of linear synthetic steps and an increase in efficiency have been realized in the synthesis of the side chain of scyphostatin. An efficient and selective synthesis of α,ω-difunctional reduced polypropionates from methyl 3-hydroxy-2-methylpropionate through the use of a Zr-catalyzed asymmetric carboalumination has been developed (see scheme, TBS=tert-butyldimethylsilyl).