Methyl-substituted alkanols have been synthesized enantioselectively (90–93 % ee) in a one-pot hydroalumination/carboalumination tandem process (see scheme). This enantioselectively represents an increase of about 15 % from the previously attainable ee values. DIBAH = diisobutylaluminum hydride, IBAO = isobutylaluminoxane.
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Huo et al. (2002) studied this question.