Which gets activated? A versatile and highly enantioselective chiral Brønsted acid catalyzed method for the propargylation of aldehydes is described to provide a range of chiral homopropargylic alcohols. Computational studies support the belief that the chiral phosphoric acid activates the allenyl boronic acid pinacol ester reagent rather than the aldehyde.
No takes yet. Share an insight, caveat, or question.
Jain et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: