Highly enantioselective trimethylsilylcyanation of various aldehydes with trimethylsilyl cyanide has been achieved with a modified Sharpless catalyst, consisting of titanium tetraisopropoxide [Ti(OPri)4] and chiral diisopropyl tartrate (DIPT). Asymmetric amplification was also observed in the trimethylsilylcyanation of benzaldehyde with a catalyst composed of Ti(OPri)4 and partially resolved DIPT.
No takes yet. Share an insight, caveat, or question.
Hayashi et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: