Key result
Venthamarai chooranam (400 mg/kg) decreased systolic blood pressure and improved plasma nitric oxide in 2K1C hypertensive rats by modulating eNOS and renin-angiotensin components.
Why the study?
Does Venthamarai chooranam reduce systolic blood pressure and modulate renin-angiotensin and endothelial signaling in a 2K1C hypertensive rat model?
RCT (n=23)
randomized
Does Venthamarai chooranam reduce systolic blood pressure and modulate renin-angiotensin and endothelial signaling in a 2K1C hypertensive rat model?
Answers are grounded in this paper and cite their sources.
Venthamarai chooranam demonstrates antihypertensive effects in a renovascular hypertensive rat model by modulating the renin-angiotensin system and improving endothelial function.
The present study was aimed to scientifically demonstrate the anti-hypertensive action of Venthamarai chooranam (VMC) in renal hypertensive rats. Two Kidney One Clip (2K1C) Goldblatt model was adopted to induce hypertension in rats. Male Sprague Dawley rats (270-320 g) were randomized into sham (n = 6), vehicle-treated 2K1C (n = 9) and VMC-treated 2K1C (400 mg/kg, p.o; n = 8) and monitored for nine weeks. Systolic blood pressure (SBP), plasma nitrate/nitrite, carotid endothelial nitric oxide synthetase (eNOS), renal angiotensin type 1 receptor (AT₁R), angiotensin type 2 receptor (AT₂R), TNFα, IL-6, thioredoxin 1 (TRX1), and thioredoxin reductase 1 (TRXR1) mRNA expressions were studied. VMC upregulated eNOS expression which in turn improved plasma nitric oxide and decreased SBP in hypertensive rats. It down-regulated AT₁R and simultaneously upregulated AT₂R expression in comparison to vehicle-treated 2K1C rats. Further, renal TNFα and IL-6 expressions were down-regulated while TRX1 and TRXR1 were upregulated by VMC. VMC potentially interacts with renin-angiotensin components and endothelial functions, and thereby exerts its antihypertensive action. This is the first study to demonstrate the mechanism of anti-hypertensive action of VMC in an animal model of renovascular hypertension.
No takes yet. Share an insight, caveat, or question.
Kalaivani et al. (2014) conducted an RCT in Renovascular hypertension (n=23). Venthamarai chooranam (VMC) vs. Vehicle-treated 2K1C was evaluated on Systolic blood pressure (SBP), plasma nitrate/nitrite, and mRNA expressions of eNOS, AT1R, AT2R, TNFα, IL-6, TRX1, and TRXR1. Venthamarai chooranam (400 mg/kg) decreased systolic blood pressure and improved plasma nitric oxide in 2K1C hypertensive rats by modulating eNOS and renin-angiotensin components.
Synapse has enriched 10 related papers. Consider them for comparative context: