The use of redox‐switched phase tags in ferrocenyl‐substituted triphenylphosphine combined with DBAD (di‐tert‐butyl azodicarboxylate) allows high yield (>90 %) Mitsunobu transformations without the need for the chromatographic purification of the products. The redox‐switchable phosphine can be easily synthesized in two steps from 4‐bromoaniline, ferrocene and chlorodiphenylphosphine. It is separated from the reaction mixture by oxidation with iron(III) chloride and can be recycled efficiently by reductive treatment.
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Fleckenstein et al. (2006) studied this question.
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