Conformationally constrained prolines (1,2) and pipecolic acids (3,4) can be synthesized stereoselectively by a novel cyclopropanation reaction. Considerable flattening of the ring can take place in the proline series. Such compounds for the preparation of peptidomimetics of therapeutic interest. Boc = tert-butoxycarbonyl.
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Hanessian et al. (1997) studied this question.
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