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Dream come true: A new monooxygenase catalyst shows excellent activity for the hydroxylation of halogenated benzenes, anisole, and toluene with almost complete ortho regioselectivity (see scheme; R=F, Cl, Br, I, CH3, OCH3). The substrates were hydroxylated at room temperature in water without cosolvent using molecular oxygen as oxidant.
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Dennig et al. (2013) studied this question.
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