A Pd-catalyzed ring-opening sulfonylation of gem -difluorocyclopropanes is reported. This protocol involves C–C bond cleavage, β-F elimination, and allylic coupling to form corresponding 2-fluoroallylic sulfones efficiently with Z -selectivity. Different substrates bearing diverse functional groups are tolerated. Moreover, this method is successfully used for the late-stage derivation of several bioactive molecules.
No takes yet. Share an insight, caveat, or question.
Ni et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: