Comparison of the Bioactive Conformations of Sialyl LewisX and a Potent Sialyl LewisX Mimic

For the rational design of drugs that inhibit the interaction between E-selectin and sialyl LewisX, structural information on bound inhibitors is required. The bioactive conformation of the potent sialyl LewisX mimic 1 was therefore determined by transfer NOE NMR spectroscopic methods.