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The first example of chromatographic separation based on isotopic chirality is shown. Diastereomers of methyl 3-phenyl-3-phenyl- d 5 -glycidate were separated by reversed-phase high-performance liquid chromatography based on the isotopic chirality provided by the presence of phenyl and phenyl- d 5 groups at one of the two chiral centers. Each of the two separated peaks was fractionated and subsequently separated into two peaks representing individual enantiomers having isotopic chirality by using a chiral stationary phase.
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Kimata et al. (1996) studied this question.
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