Organocatalytic Synthesis of Highly Functionalized Pyridines at Room Temperature

Amines by all means: A unique aza-Rauhut–Currier/cyclization/desulfonation cascade reaction between allenoates and N-sulfonyl-1-aza-1,3-dienes, catalyzed by the readily available diamine TMEDA, has been developed. This strategy provides facile access to a broad range of valuable highly functionalized pyridines in good yields under very mild reaction conditions.