Key result
Irradiation combined with adriamycin resulted in fatal hepatopathy in one case and moderate clinical changes in another, suggesting locally enhancing effects of adriamycin on hepatic tolerance.
Case Report (n=2)
Adriamycin may locally enhance the effects of irradiation on hepatic tolerance, leading to hepatopathy at doses usually considered safe.
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Alerts clinicians to possible adriamycin-enhanced radiation hepatotoxicity; leaves open generalizability and dose thresholds for confirmation.
This report describes two cases of hepatopathy following irradiation and adriamycin at doses and volumes of irradiation ordinarily considered within the tolerance of hepatic function. In one case fatal hepatopathy followed 2400 rad/17 fractions/28 days to the entire liver with preceding and concurrent adriamycin. In the second case moderate clinical changes occurred after treatment in which much of the right lobe of the liver was shielded following 2500 rad/23 fractions/32 days with adriamycin administered before, during, and after irradiation. The locally enhancing effects of adriamycin on hepatic tolerance to irradiation are discussed.
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Kun et al. (1978) conducted a case report in Hepatopathy (n=2). Irradiation and adriamycin was evaluated on Hepatopathy. Irradiation combined with adriamycin resulted in fatal hepatopathy in one case and moderate clinical changes in another, suggesting locally enhancing effects of adriamycin on hepatic tolerance.
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