Key result
Hepatitis B surface antigen particles could be distinguished from low density lipoprotein molecules by electron microscopy, with specific antiserum significantly reducing the mean diameter of LDL.
Electron microscopy can distinguish between HBsAg particles and LDL molecules based on contrast and response to specific antiserum.
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Electron microscopy distinction of HBsAg from LDL is experimental; leaves open any role in human diagnostics or pathogenesis research.
The small spherical particles associated with hepatitis B surface antigen (HBsAg) could be distinguished from the low density lipoprotein (LDL) molecules in human serum by examination of coded, negatively stained preparations. The HBsAg associated particles showed a more marked contrast against the background than LDL. Addition of specific antiserum to LDL caused a significantly reduced mean diameter of LDL molecules. An insignificant reduction in size of HBsAg particles was found by corresponding treatment. It is suggested that the antibody molecules protect LDL molecules protect LDL molecules against artificial flattening during preparation.
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Marit Hornberg Solaas (1978) studied Hepatitis B. Hepatitis B surface antigen (HBsAg) particles vs. Low density lipoprotein (LDL) molecules was evaluated on Visual contrast and mean diameter by electron microscopy. Hepatitis B surface antigen particles could be distinguished from low density lipoprotein molecules by electron microscopy, with specific antiserum significantly reducing the mean diameter of LDL.
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