Key result
This article provides clinical guidance on risk thresholds and the use of antepartum and postpartum low-molecular-weight heparin prophylaxis in women with known thrombophilia or prior VTE.
Why the study?
Does low-molecular-weight heparin prophylaxis prevent venous thromboembolism in pregnant and postpartum women with known thrombophilia or prior VTE?
Does low-molecular-weight heparin prophylaxis prevent venous thromboembolism in pregnant and postpartum women with known thrombophilia or prior VTE?
This review provides guidance on balancing thrombotic and bleeding risks when considering LMWH prophylaxis for pregnant and postpartum women with thrombophilia or prior VTE.
Risk thresholds for LMWH prophylaxis in thrombophilic pregnancy require individualized assessment; leaves open standardized recommendations pending higher-level evidence.
When should a patient with a known thrombophilia or prior venous thromboembolism (VTE) receive low-molecular-weight heparin (LMWH) prophylaxis during pregnancy and/or the postpartum period? Accurately predicting thrombotic and bleeding risks and knowing what to do with this information is at the heart of decision-making in these challenging scenarios. This article will explore the concept of a risk threshold from clinician and patient perspectives and provide guidance for the use of antepartum and postpartum LMWH prophylaxis in women with a known thrombophilia or prior VTE. Advice for the management of LMWH prophylaxis use around labor and delivery is also reviewed.
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Leslie Skeith (2017) conducted a review in Venous thromboembolism during pregnancy and postpartum. Low-molecular-weight heparin (LMWH) prophylaxis was evaluated. This article provides clinical guidance on risk thresholds and the use of antepartum and postpartum low-molecular-weight heparin prophylaxis in women with known thrombophilia or prior VTE.
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