BMDTCA formation of anticoagulant fibrinogen degradation products aggravates the haematologic defect.Moreover, to control the replacement of fibrinogen, as is suggested, is difficult, since the laboratory tests com- monly employed in acute fibrinolytic conditions (thrombin time, Fibrindex, etc.) are at best semi-quantitative.Even if a rapid method of fibrinogen estimation is used' the findings can be misleading, for the blood level of fibrinogen may be higher than that indicated by the test owing to the presence of anticoagulant fibrinogen degradation pro- ducts.'In our experience in obstetrical patients' ' the clinical condition of the patient may be a better guide to therapy than the fibrinogen level determined in the laboratory, and fresh whole blood is a better substitute than fibrinogen alone.Lastly, the risk of E.A.C.A. causing intravascular thrombosis (apart from that presented by the original stimulus for defibrination) when it is given for a rela- tively short period (as in acute obstetrical conditions) is negligible.This is because the drug is excreted through the kidneys very rapidly.-Iam, etc.,
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W Drukker (1968) studied this question.
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