Key result
Acutely induced hypoglycaemia did not cause significant alterations in 24-hour blood pressure, although it induced a temporary fall in mean BP in diabetic patients (-7 vs -2 mmHg; p<0.05).
Why the study?
Does acutely induced hypoglycaemia alter 24-hour blood pressure and heart rate in Type 1 diabetic and normal subjects?
Does acutely induced hypoglycaemia alter 24-hour blood pressure and heart rate in Type 1 diabetic and normal subjects?
Absolute Event Rate: -7% vs -2%
p-value: p=<0.05
Acute hypoglycaemia does not cause significant delayed alterations in 24-hour blood pressure or heart rate in either Type 1 diabetic or normal subjects.
Acute hypoglycaemia appears safe for 24-hour BP in T1D; leaves open whether recurrent episodes alter long-term CV risk.
This study was performed to assess possible delayed after-effects of acute hypoglycaemia on blood pressure (BP) and heart rate (HR) over a 24-h period. Eleven insulin-dependent diabetic patients and 11 sex, age, and body mass index matched non-diabetic subjects were studied. Blood pressure was measured using a non-invasive ambulatory blood pressure monitor following acutely induced hypoglycaemia in the morning. No significant differences were observed in 24-h systolic and diastolic BP and HR in either groups, between the day when hypoglycaemia was induced and the day when plasma glucose was kept normal. In diabetic patients, hypoglycaemia induced a temporary but significant fall in mean BP (-7 +/- 1 mmHg vs -2 +/- 2; p < 0.05). Plasma glucose levels were significantly higher in insulin-dependent diabetic patients following hypoglycaemia than in those observed during the reference test. This study demonstrates that acute hypoglycaemia in insulin-dependent diabetic subjects does not cause significant alterations in 24-h BP in either diabetic or normal subjects.
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Avogaro et al. (1994) studied Type 1 (Insulin-dependent) Diabetes (n=22). Acutely induced hypoglycaemia vs. Day when plasma glucose was kept normal was evaluated on Temporary fall in mean blood pressure in diabetic patients (p=<0.05). Acutely induced hypoglycaemia did not cause significant alterations in 24-hour blood pressure, although it induced a temporary fall in mean BP in diabetic patients (-7 vs -2 mmHg; p<0.05).
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