Impact of Insulin Concentrations and Insulin Resistance on Lung Function and Morbidity in Asthma

This is the authors' abstract. We don't add key points for this paper.

Prior work has shown insulin resistance (IR) modifies the association between obesity and asthma1 and is associated with decreased lung function in adolescents and children with asthma in cross-sectional national surveys,2 providing a potential mechanistic pathway driving obesity-associated asthma. IR has been shown to be associated with decreased lung function and increased lung function decline in the Severe Asthma Research Program (SARP-3) cohort.3 Hyperinsulinemia has been shown to lead to bronchoconstriction in animal models but remains an unstudied mechanistic pathway in humans with asthma.