The Systemic Manifestations of Sjögren's Syndrome: Report of Glandular Function With Histologic, Bacterial and Viral Studies

Case Reports1 June 1958THE SYSTEMIC MANIFESTATIONS OF SJÖGREN'S SYNDROME: REPORT OF GLANDULAR FUNCTION WITH HISTOLOGIC, BACTERIAL AND VIRAL STUDIESMARTIN E. GORDON, M.D., EDWARD SHANBROM, M.D.MARTIN E. GORDON, M.D.Search for more papers by this author, EDWARD SHANBROM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-6-1342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1933 Henrik Sjögren1 amplified Gougerot's original description2 of a syndrome consisting of dryness of the mucous membranes and the eyes, with parotid glandular enlargement in menopausal women. Since then several excellent reviews3, 4, 5 have emphasized that the disease is of a diverse nature, with such manifestations as polyarthritis, dryness of the vulva and vagina, diminished perspiration, Raynaud's phenomena, scleroderma, hypochromic anemia, alopecia, achylia gastrica and an altered glucose tolerance.Infrequent attempts6, 7, 8have been made to study the pathogenesis of this condition by noting histopathologic changes occurring in accessible organs. The following report is an evaluation of...Bibliography1. Sjögren H: Zur Kenntnis der Keratoconjunctivitis Sicca, Acta ophth. Supp. 2: 1-151, 1933. Google Scholar2. Gougerot H: Insuffisance progressive et atrophie des glandes salivaires et muqueuses de la bouche, des conjunctives (et parfois des muqueuses nasale, laryngee, vulvaire): "Secheresse" de la bouche, conjunctives, etc. Bull. Soc. franç. de dermat. et syph. 32: 376, 1925. Google Scholar3. MorganRaven ADRW: Sjögren's syndrome: a general disease, Brit. J. 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WILSON JR., M.D.Pararheumatische Krankheiten (Sogenannte Kollagenkrankheiten)Sjögren's Syndrome with Benign Purpura Hyperglobulinemia 1 June 1958Volume 48, Issue 6Page: 1342-1359KeywordsGlucose toleranceHospital medicineHyperglobulinemiaInoculationMedical servicesMucous membranesPathogenesisSclerodermaSweatVagina ePublished: 1 December 2008 Issue Published: 1 June 1958 PDF downloadLoading ...