Preparation of MnO 2 @poly (DMAEMA-co-IA) Conjugated methotrexate Nano-complex for MRI and Radiotherapy of Breast Cancer Application

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A novel efficient pH-sensitive targeted magnetic resonance imaging (MRI) contrast agent and innovative radiosensitizing system were synthesized based on MnO2 NPs coated with biocompatible poly (dimethylaminoethyl methacrylate -Co- itaconic acid) and targeted with methotrexate. The established NPs were characterized and MRI signal enhancement, relaxivity, cell targeting, toxicity, and radiotherapy efficacy were evaluated. The developed system displayed pH-responsive MRI contrast enhancement, differential uptake in malignant and normal cells, negligible in vitro cytotoxicity, and suitable in vitro cell targeting ability. Enhanced therapeutic efficacy in hypoxic conditions confirmed the efficiency of the system in MR imaging and radiation therapy of hypoxia cells.