The solution conformation of adriamycin was studied by 1H nuclear magnetic resonance spectroscopy. The hydrochloride was found to be rigid on the nmr time scale in each of CDCl3, DMF-d7, and DMSO-d6. The sugar and D rings were found to have the same conformations as were found previously by X-ray crystallography. Similar results were found for the free base in DMF-d7 and CDCl3 solutions although the free base was found to be conformationally mobile in acetone-d6 and CD3OD solutions.
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Allman et al. (1987) studied this question.