Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1979The Journal of Organic Chemistry

Nogalamycin. Stereochemistry and chemical modification

View Full Paper
Ask AI
Bookmark
Share

Authors

PWPaul F. WileyBoston UniversityDEDavid W. ElrodPfizer (United States)DHDavid J. HouserFive Prime Therapeutics (United States)

Discussion

Loading...

Member takes

Implication

Structural analysis reveals the stereochemistry and synthetic modifications of nogalamycin, suggesting strategies to optimize anthracycline drug design.

Key Points

  • Determine the complete stereochemical configuration of the antibiotic nogalamycin and evaluate pathways for its chemical modification.
  • Applied selective chemical degradation and functionalization reactions to the nogalamycin scaffold.
  • Characterized structural conformations and chiral centers using spectroscopic analysis and circular dichroism.
  • Assigned the three-dimensional stereochemical configurations for the aglycone and sugar components of the nogalamycin core.
  • Synthesized functionalized nogalamycin derivatives through targeted chemical modifications of reactive functional groups.

Cite This Study

Wiley et al. (1979) studied this question.

synapsesocial.com/papers/6a938fdb744b618ad237d543https://doi.org/10.1021/jo01337a002
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure of nogalamycin1977 · 90 citations
  2. 2Useful chemistry of 3-(1-methylethylidene)-4-acetoxy-2-azetidinones: a formal synthesis of (.+-.)-asparenomycin C1985 · 77 citations
  3. 3Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 20092010 · 85 citations
  4. 4Green Chemistry Articles of Interest to the Pharmaceutical Industry2024 · 2 citations
  5. 5An efficient stereospecific total synthesis of (.+-.)-anisomycin and related new synthetic antibiotics1982 · 45 citations