Synthetic luteinizing hormone-releasing hormone was given to six patients (3 men and 3 women) with active acromegaly. All three men had rapid increases in growth hormone, as well as luteinizing and follicle-stimulating hormones. This represents further evidence that the pituitary gland remains under hypothalamic control in some cases of acromegaly.
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Rubin et al. (1973) studied this question.