Why the study?
Does surgical excision combined with chemotherapy improve survival outcomes in patients with desmoplastic small round cell tumor compared to chemotherapy alone?
Cohort (n=18)
Does surgical excision combined with chemotherapy improve survival outcomes in patients with desmoplastic small round cell tumor compared to chemotherapy alone?
Answers are grounded in this paper and cite their sources.
Surgical excision combined with chemotherapy significantly improves survival outcomes in patients with desmoplastic small round cell tumor compared to chemotherapy alone.
OBJECTIVE: To investigate the clinicopathologic features and survival outcomes of desmoplastic small round cell tumor (DSCRT). METHODS: The retrospective cohort study was performed on clinical and pathological data of 18 DSCRT patients. Among them, two subgroups were classified according to treatment modalities. 10 cases underwent operation and adjuvant chemotherapy (group 1, 10/18, 55.6%) and 8 cases were diagnosed by fine needle aspiration biopsy without surgical intervention (group 2, 8/18, 44.4%). All cases received six courses of multiple agents chemotherapy. RESULTS: All cases were histologically confirmed as DSRCT and Cox regression revealed that sex, tumor localization and treatment modality affected patient outcomes. Kaplan-Meier analysis revealed that the median survival time was 22.0 ± 4.0 mo in group 1 versus 9.0 ± 0.7 mo in group 2. CONCLUSION: DSRCT is highly aggressive malignance with poor prognosis, surgical excision with combination of chemotherapy can significantly improve the survival outcomes.
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Tang et al. (2015) conducted a cohort in Desmoplastic small round cell tumor (DSCRT) (n=18). Operation and adjuvant chemotherapy vs. Chemotherapy without surgical intervention was evaluated on Median survival time.
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