Key result
Young adults of South Asian ethnicity with hypertension had a higher prevalence of elevated aortic pulse wave velocity (>10 m/s) compared to Europeans (46.9% vs 22.2%), despite lower average blood pressure.
Why the study?
Cardiovascular risk needed evaluation based on arterial stiffness and adipokine content in young individuals of European and South Asian ethnicity.
Cross-Sectional (n=290)
Traditional cardiovascular risk scales may underestimate risk in young South Asians, who exhibit earlier vascular remodeling and increased aortic stiffness compared to Europeans.
Answers are grounded in this paper and cite their sources.
Traditional scales may underestimate CVR in young South Asians; leaves open whether adipokines drive ethnic differences in arterial stiffness.
AIM: To evaluate the cardiovascular risk (CVR) based on arterial stiffness and content of adipokines in young-aged persons of different ethnicity (European and South Asian). MATERIALS AND METHODS: 290 persons of European (Slavic) and South Asian (Korean) ethnicity aged from 19 to 49 years with and without arterial hypertension (AH) were examined. Clinical, anthropometric, laboratory examinations were performed, levels of resistin and adiponectin of blood were assessed. Total CVR was assessed by SCORE scale, patients under the age of 40 years were assessed by relative risk scale. Aortic stiffness was examined by non-invasive arteriography. RESULTS: Patients of European ethnicity had higher blood pressure (BP), body mass index (BMI), waist circumference (WC), levels of resistin and adiponectin. Pulse wave velocity in the aorta (PWVA) did not differ significantly in ethnic groups. According to the SCORE scale in individuals of the European and South Asian races in general groups and groups with arterial hypertension a moderate absolute risk was determined, in individuals under 40 years of age a moderate relative risk was determined without a significant difference between the groups. However increased levels of PWVA (more than 10 m/s) were registered more often in Korean ethnicity (46.9% compared to Slavic ethnicity, 22.2%). Closer reliable correlations between the level of BP and BMI, WC, PWVA were revealed in Korean ethnicity. Ethnic differences in correlation of adipokines in blood and their dependence on anthropometric and hemodynamic characteristics were described. CONCLUSION: The assessment of CVR according to traditional scales does not always accurately represent its real level. New information was obtained on the features of adipokine metabolism and its connections with early manifestations of vascular remodeling in young-aged depending on the race. Taking into account ethnic differences, we recommend in-depth diagnostics of CVR in South Asians. The data can be useful for the design of personalized programs for the diagnostics and assessment of CVR.
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Brodskaya et al. (2021) conducted a cross-sectional in Hypertension and Cardiovascular Risk (n=290). South Asian ethnicity vs. European ethnicity was evaluated on Aortic pulse wave velocity > 10 m/s in patients with hypertension. Young adults of South Asian ethnicity with hypertension had a higher prevalence of elevated aortic pulse wave velocity (>10 m/s) compared to Europeans (46.9% vs 22.2%), despite lower average blood pressure.
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