Key result
Three-dimensional reconstructions of measles virus nucleocapsids support a model placing the RNA at the exterior of the helix and the disordered C-terminal domain toward the helix interior.
The study provides a 3D structural model of the measles virus nucleocapsid, suggesting the RNA is located on the exterior of the helix.
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No immediate clinical implications from this animal model; leaves open validation and therapeutic translation of the nucleocapsid architecture.
Recombinant measles virus nucleoprotein-RNA (N-RNA) helices were analyzed by negative-stain electron microscopy. Three-dimensional reconstructions of trypsin-digested and intact nucleocapsids coupled to the docking of the atomic structure of the respiratory syncytial virus (RSV) N-RNA subunit into the electron microscopy density map support a model that places the RNA at the exterior of the helix and the disordered C-terminal domain toward the helix interior, and they suggest the position of the six nucleotides with respect to the measles N protomer.
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Desfosses et al. (2010) studied Measles Virus. Three-Dimensional Electron Microscopy was evaluated. Three-dimensional reconstructions of measles virus nucleocapsids support a model placing the RNA at the exterior of the helix and the disordered C-terminal domain toward the helix interior.
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