Key result
A review of severe radiation accidents in the United States highlights 4 criticality cases that provide key insights into the pathophysiology and clinical evolution of multi-organ failure.
Review of severe radiation accidents in the US highlights the pathophysiology of multi-organ failure where supportive care did not alter clinical evolution.
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Suggests supportive care may not alter outcomes in radiation multi-organ failure; leaves open need for targeted therapies pending validation.
Only a small number of radiation accidents in the United States have been severe enough to result in multi-organ failure (MOF). Medical details of selected medical misadministration and criticality cases are reviewed, with an emphasis on pathophysiology. The four criticality cases are particularly relevant for analysis of MOF, since medical treatment was supportive and did not appreciably alter the clinical evolution of radiation injury.
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Goans et al. (2005) conducted a review in Radiation accidents with multi-organ failure. Severe radiation exposure was evaluated on Multi-organ failure. A review of severe radiation accidents in the United States highlights 4 criticality cases that provide key insights into the pathophysiology and clinical evolution of multi-organ failure.
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