Key result
Electrical stimulation of baroreceptor afferents in the aortic depressor nerve produced hindlimb vasodilation that was significantly diminished by the neuronal NO synthase inhibitor 7-nitroindazole.
Hindlimb vasodilation produced by electrical stimulation of baroreceptor afferents may involve activation of postganglionic lumbar sympathetic vasodilator fibers releasing nitrosyl factors.
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Suggests neuronal NO involvement in sympathetic vasodilation; hypothesis-generating in animals and leaves open human translation.
Possas et al. (2005) studied this question. Electrical stimulation of the baroreceptor afferent fibers in the aortic depressor nerve (ADN) with or without 7-nitroindazole was evaluated on Reductions in mean arterial blood pressure (MAP) and mesenteric and hindlimb vascular resistance. Electrical stimulation of baroreceptor afferents in the aortic depressor nerve produced hindlimb vasodilation that was significantly diminished by the neuronal NO synthase inhibitor 7-nitroindazole.
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