Key result
Tetrabutylammonium ion induces a voltage-dependent flickery block of the anthrax toxin PA65 channel, with blocking rates plateauing at large positive voltages consistent with a diffusion-limited entry.
Population
Planar phospholipid bilayer membranes containing channels formed by the PA65 fragment of anthrax toxin
Design
Preclinical
Authors
Loading...
Provides no immediate clinical guidance; leaves open whether tetrabutylammonium derivatives merit investigation as anthrax countermeasures.
This single-channel analysis demonstrates that tetrabutylammonium ions induce a voltage-dependent flickery block of anthrax toxin PA65 channels and can permeate the channel at high positive voltages.
Blaustein et al. (1990) studied this question. Tetrabutylammonium ion (Bu4N+) vs. Absence of Bu4N+ was evaluated on Mean blocked and unblocked times of PA65 channels. Tetrabutylammonium ion induces a voltage-dependent flickery block of the anthrax toxin PA65 channel, with blocking rates plateauing at large positive voltages consistent with a diffusion-limited entry.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: