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SUMMARY The quantitative determination of exophthalmogenic activity in pituitary fractions by means of a cross-over bioassay in Carassius auratus is described. The ratio of exophthalmogenic to thyrotrophic activity of eight bovine pituitary fractions has been determined. Contrary to previous claims no dissociation of the two biological activities could be demonstrated. Reasons for the discrepancy are discussed.
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Dedman et al. (1967) studied this question.
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