The effect of chlorpropamide upon the polyuria of diabetes insipidus was studied in nine patients. In seven patients suffering from the idiopathic type a normal or almost normal diuresis, not exceeding two liters, has been obtained. In the nephrogenic type chlorpropamide had no effect upon the polyuria. In the polyuric phase after hypophysectomy a striking effect was seen.
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Frøyshov et al. (1968) studied this question.
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