Drug Induced Interstitial Nephritis, Hepatitis and Exfoliative Dermatitis

Summary: Drug induced interstitial nephritis, hepatitis and exfoliative dermatitis. Robyn A. McMenamin, L M. Davies and P. W. Craswell, Aust. N.Z. J. Med., 1976, 6, pp. 583–587. Acute interstitial nephritis associated with hepatitis, exfoliative dermatitis, fever and eosinophilia is uncommon. The syndrome has been described previously in association with phenindione administration, leptospir‐osis and heavy metal poisoning. Four cases are described, two of which were due to phenindione sensitivity. The other two patients had been exposed to a number of toxins inclucling allopurinol, frusemide, chlorothiazide and methyldopa so that the exact aetiological agent is unclear. Interstitial nephritis should be considered as a cause of acute renal failure in patients with other features of drug hypersensitivity.