Sarcoid Reaction Associated with Phenylbutazone Hypersensitivity

Case Studies1 July 1963Sarcoid Reaction Associated with Phenylbutazone HypersensitivityGIDEON GOLDSTEIN, M.B., B.S.GIDEON GOLDSTEIN, M.B., B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-97 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis case report describes a hypersensitivity reaction to the analgesic drug, phenylbutazone. The clinical features included fever, rash, and enlargement of lymph nodes, liver, and spleen. The histological changes in the liver and a scalene lymph node were of particular interest in showing a sarcoid reaction. The patient recovered fully.CASE REPORTA 44-year-old housewife presented on March 12, 1962, with pains in the back and shoulders of 2 years' duration; rash, fever, sore throat, dizziness, and blurring of vision had been present for 2 weeks. She had been treated 8 weeks previously with sulphadimethoxine (Madribon) for pyelitis and with...References1. MAUER EF: The toxic effects of phenylbutazone (Butazolidin); review of the literature and report of the twenty-third death following its use. New Eng. J. Med. 253: 404, 1955. CrossrefMedlineGoogle Scholar2. STEINBROCKERARGYROS OTG: Phenylbutazone as a therapeutic agent in rheumatic diseases: its present status. Arthritis Rheum. 3: 368, 1960. CrossrefMedlineGoogle Scholar3. STEINBERGBOHRODROODENBURG CLMGAI: Agranulocytosis following phenylbutazone (Butazolidin) therapy. JAMA 152: 33, 1953. CrossrefMedlineGoogle Scholar4. SCHWARTZMARSHALLROBINSON NHDBD: Phenylbutazone toxicity resulting in severe systemic reaction. New York J. Med. 54: 265, 1954. MedlineGoogle Scholar5. CHARETSIEGEL RI: Unusual reaction following use of phenylbutazone (Butazolidin). JAMA 151: 556, 1953. CrossrefMedlineGoogle Scholar6. FREIMAN DG: Sarcoidosis. New Eng. J. Med. 239: 664, 709, 743, 1948. CrossrefMedlineGoogle Scholar7. LONGCOPEFREIMAN WTDG: A study of sarcoidosis based on combined investigation of 160 cases including 30 autopsies from Johns Hopkins Hospital and Massachusetts General Hospital. Medicine (Balt.) 31: 1, 1952. CrossrefMedlineGoogle Scholar8. MICHAEL M: Sarcoidosis: disease or syndrome. Amer. J. Med. Sci. 235: 148, 1958. CrossrefMedlineGoogle Scholar9. RABEN AS: Sarcoidosis and so-called sarcoid reactions. Postgrad. Med. 31: 232, 1962. CrossrefMedlineGoogle Scholar10. KLATSKINYESNER GR: Hepatic manifestations of sarcoidosis and other granulomatous diseases: study based on histological examination of tissue obtained by needle biopsy of the liver. Yale J. Biol. Med. 23: 207, 1950. MedlineGoogle Scholar11. BURNET FM: The Clonal Selection Theory of Acquired Immunity, Cambridge University Press, Cambridge, 1959, p. 161. CrossrefGoogle Scholar12. WAKSMAN BH: Auto-immunization and the lesions of auto-immunity. Medicine (Balt.) 41: 93, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Melbourne,From the Clinical Research Unit of the Royal Melbourne Hospital and The Walter & Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.Supported by a grant from the Drug Houses of Australia.Requests for reprints should be addressed to Gideon Goldstein, M. B., Clinical Research Unit, The Royal Melbourne Hospital, The Walter & Eliza Hall Institute of Medical Research, Royal Melbourne Hospital Post Office, Melbourne, Australia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced Respiratory Disease in Connective Tissue DiseasesIatrogenia a fármacos no contexto do Aparelho RespiratórioIdiosyncratic Liver Toxicity of Nonsteroidal Antiinflammatory Drugs: Molecular Mechanisms and PathologyHypersensitivity pneumonitisSarcoidosisGranulomatous Liver Disease: Clinical Aspects11 Drug-induced and toxic granulomatous hepatitisCase Report Fatal Methyldopa — Associated Granulomatous Hepatitis and MyocarditisPhenylbutazone liver injury: A clinical-pathologic survey of 23 cases and review of the literatureReversible Bone Marrow Granulomas-Adverse Effect of Oxyphenbutazone TherapyDrug-Induced Liver Reactions: A Morphological ApproachClinical Utilization of Alkaline Phosphatase MeasurementsProceedings of the Joint Meeting of the Belgische Vereniging voor Pneumologie (Societe Belge de Pneumologie) and the Thoracic Society. Bruges 20-21 April 1978. Summaries of papers.Antirheumatika und LeberGranulomas and cholestatic-hepatocellular injury associated with phenylbutazoneChronic Granulomatous HepatitisQuinidine Hypersensitivity and Liver InvolvementLiver Disease Due to Infection and AllergyQuinidine-lnduced Granulomatous HepatitisT. CHAJEK, M.D., B. LEHRER, M.B., Ch.B., D. GELTNER, M.D., I. S. LEVIJ, M.D.Cryptococcal Hepatitis Mimicking Primary Sclerosing CholangitisGUIDELINES FOR DIAGNOSIS OF THERAPEUTIC DRUG-INDUCED LIVER INJURY IN LIVER BIOPSIESHydralazine Disease Associated With Transient Granulomas in the LiverIntrahepatic Cholestasis Due to Therapy of Rheumatoid ArthritisCytologic and Histologic Aspects of Toxically Induced Liver ReactionsGranulomatous Hepatitis in a Patient Receiving AllopurinolDRUG REACTIONS XII Cutaneous Reactions to Anti-rehumatic DrugsSarcoidosisDrug-induced lung diseaseZur Immunologie der SarkoidoseErste wissenschaftliche Sitzung 1 July 1963Volume 59, Issue 1_Part_1Page: 97-100KeywordsFeversHypersensitivityLiverLymph nodesPharyngitisProteinsRashesShouldersSpleenVision ePublished: 1 December 2008 Issue Published: 1 July 1963 PDF downloadLoading ...