Key result
Simple sugars, particularly glucose and galactosamine, as well as dextran sulfates, interfered with the uptake of Encephalomyocarditis virus by cells and inhibited hemagglutination.
Population
Erythrocytes from human, rat, guinea pig, and rabbits; rabbit brain tissue; various mouse tissues
Design
Preclinical
Authors
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Animal data only; leaves open sugar-receptor targeting as a research avenue for EMCV myocarditis models.
Simple sugars and specific chemical treatments inhibit Encephalomyocarditis virus hemagglutination and cell uptake, suggesting specific sugar-receptor interactions in virus-cell union.
Calvin M. Kunin (1967) studied Encephalomyocarditis virus-cell union. Simple sugars (glucose, galactosamine) and dextran sulfates was evaluated on Hemagglutination and virus uptake by cells. Simple sugars, particularly glucose and galactosamine, as well as dextran sulfates, interfered with the uptake of Encephalomyocarditis virus by cells and inhibited hemagglutination.
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