Although GABA has figured prominently in theories of migraine pathogenesis,1 brain levels of this transmitter have not been directly measured in migraineurs. This is of importance since, in migraine, neurophysiologic events account for brain hyperexcitability and subcortical disinhibition.2,3 Magnetic resonance spectroscopy (MRS) measures levels of metabolites in the human brain and may map regional changes in their levels.4 Accordingly, herein we used MRS to measure the levels of GABA in individuals with migraine with aura (MA), migraine without aura (MO), and in controls.
No takes yet. Share an insight, caveat, or question.
Bigal et al. (2008) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: