Seeing the light: Upon binding to a complementary nucleic acid, a metal-complex–DNA conjugate releases copper(II) ions that activate the precatalyst 1,10-phenanthroline (phen) and amplify the primary signal through catalytic production of a fluorescent dye (DCF). This combination of allosteric signal transduction and catalytic signal amplification imitates biological signaling cascades. tpy=2,2′:6′,2′′-terpyridine.
No takes yet. Share an insight, caveat, or question.
Graf et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: