Building bridges: A Lewis acid promoted intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with aldehydes, ketones, and imines (see scheme) has been developed to provide a general and efficient strategy for construction of bridged oxa- and aza-[n.2.1] (n=2,3,4) skeletons. To highlight this method, the core of platensimycin was also constructed.
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Xing et al. (2010) studied this question.
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