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January 1, 2016RSC Advances

A one-pot multicomponent facile synthesis of dihydropyrimidin-2(1H)-thione derivatives using triphenylgermane as a catalyst and its binding pattern validation

Sohaila Andleeb Imtiaz Ud Din Muhammad Khawar Rauf Syed Sikander Azam Amin Badshah Haseeba Sadaf Ahmed Raheel Muhammad Nawaz Tahir Saad Raza

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Abstract

A series of substituted dihydropyrimidin-2(1 H )-thione derivatives ( 1–8 ) have been synthesized and docked against enzymes human topoisomerase II alpha (4FM9) and Helicobacter pylori urease (1E9Y) for binding mode validation.

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Andleeb et al. (2016) studied this question.

synapsesocial.com/papers/6a93a00b40aff459acebbe09 https://doi.org/10.1039/c6ra19162b

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1An Efficient and Clean One-Pot Synthesis of 3,4-Dihydropyrimidine-2-(1H)-ones Catalyzed by SrCl2.6H2O-HCl in Solvent or Solvent-Free ConditionsOriginal Research · 2005 · 25 citations
2Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridinesOriginal Research · 1990 · 284 citations
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5Three Component Reaction: An Efficient Synthesis and Reactions of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Using New Natural CatalystOriginal Research · 2013 · 19 citations

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