IL-10 was originally described as a cytokine produced by Th2 cells and mediating antiinflammatory effects, by acting primarily on phagocytic cells and on antigen-presenting cells ([1][1]). IL-10 inhibits, in these cells, transcription and production of proinflammatory cytokines, such as TNF and IL-
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Giorgio Trinchieri (2001) studied this question.
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