Key result
Thrombocytopenia significantly reduced survival during murine pneumococcal pneumonia compared to controls (27% vs 75%; p=0.003).
Why the study?
Does platelet depletion or inhibition worsen outcomes in murine pneumococcal pneumonia?
Does platelet depletion or inhibition worsen outcomes in murine pneumococcal pneumonia?
Platelets play a protective role during pneumococcal pneumonia independent of their aggregation, as thrombocytopenia but not clopidogrel worsened survival and bacterial clearance.
Platelet depletion worsens murine pneumococcal pneumonia survival; leaves open platelets' protective role in human infection.
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Boogaard et al. (2015) studied Murine pneumococcal pneumonia. Thrombocytopenia (induced by anti-mouse thrombocyte serum) vs. Nonimmunogenic serum was evaluated on Survival (p=0.003). Thrombocytopenia significantly reduced survival during murine pneumococcal pneumonia compared to controls (27% vs 75%; p=0.003).
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