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March 26, 2013Biochemical Journal

Molecular orientation of Factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer

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Authors

HWHironao WakabayashiUniversity of Rochester Medical CenterPFPhilip J. FayPhilips (Finland)

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Wakabayashi et al. (2013) studied this question.

synapsesocial.com/papers/6a93a6e6213a779dfe720981https://doi.org/10.1042/bj20130025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression and Characterization of Recombinant Murine Factor VIII2002 · 71 citations
  2. 2Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside1981 · 681 citations
  3. 3Trp2063and Trp2064in the Factor Va C2 Domain Are Required for High-Affinity Binding to Phospholipid Membranes but Not for Assembly of the Prothrombinase Complex2004 · 26 citations
  4. 4Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity1986 · 423 citations
  5. 5Ca2+ Binding to Both the Heavy and Light Chains of Factor VIII Is Required for Cofactor Activity2002 · 37 citations