Key result
An algorithmic approach was proposed to diagnose and treat hypertension in pediatric acute lymphoblastic leukemia patients, addressing the lack of clear guidelines.
Why the study?
Hypertension is a recognized side effect of childhood ALL therapy, but prevalence data are limited and clear guidelines for managing inpatient hypertension in this population are lacking.
This review highlights the prevalence and risk factors of hypertension in pediatric ALL patients and proposes a structured algorithmic approach for its diagnosis and management.
May inform hypertension monitoring in pediatric ALL; leaves open prospective validation of the proposed algorithm.
Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children under the age of 18. While modern diagnostic technologies, risk-stratification, and therapy intensification have led to outstanding outcomes for many children with ALL, the side effects and consequences of therapy are not to be underestimated. Hypertension is a well-known acute and chronic side effect of treatment for childhood ALL, although limited data are available regarding the prevalence of hypertension in children undergoing treatment for ALL. In this review of hypertension in pediatric ALL patients, we examine the existing data on incidence and prevalence during treatment and in pediatric ALL survivors. We describe independent risk factors for development of hypertension along with treatment-related causes. Long-term consequences and the risk to survivors of pediatric ALL are further defined. While many ALL patients require antihypertensive medications during some portion of their treatment, there are no clear guidelines on treating inpatient hypertension given challenges that exist in recognizing and managing hypertension in this setting and in this population. Here, we propose an algorithmic approach to diagnose and treat pediatric ALL patients with HTN, along with monitoring and continuation versus cessation of antihypertensive therapy as an outpatient.
No takes yet. Share an insight, caveat, or question.
A 2022 study conducted a review in Hypertension in pediatric acute lymphoblastic leukemia (ALL). Algorithmic approach to diagnose and treat hypertension was evaluated. An algorithmic approach was proposed to diagnose and treat hypertension in pediatric acute lymphoblastic leukemia patients, addressing the lack of clear guidelines.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: