Key result
Nifedipine competitively antagonized ATP-evoked contractions (pA2 8.23) and intracellular Ca2+ elevation in guinea-pig urinary bladder, suggesting ATP activates dihydropyridine-sensitive Ca2+ channels.
Population
Thin outer layer segment of guinea-pig urinary bladder
Comparison
Nifedipine and other dihydropyridine-type… vs Other antagonists or baseline ATP response
Design
Preclinical
Authors
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Nifedipine may modulate ATP-driven detrusor contractions in this model; leaves open relevance to human bladder physiology or therapy.
Effect estimate: pA2 8.23
Nifedipine competitively inhibits ATP-evoked contraction and calcium influx in guinea-pig urinary bladder, suggesting ATP activates dihydropyridine-sensitive calcium channels.
Katsuragi et al. (1990) studied this question. Nifedipine was evaluated on ATP-evoked contraction and increase of intracellular Ca2+ (pA2 8.23). Nifedipine competitively antagonized ATP-evoked contractions (pA2 8.23) and intracellular Ca2+ elevation in guinea-pig urinary bladder, suggesting ATP activates dihydropyridine-sensitive Ca2+ channels.
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