Key result
Vagotomy and carotid sinus denervation did not prevent the diuretic and chloruretic response to plasma volume expansion, suggesting additional receptors contribute to regulating plasma volume.
Why the study?
Does vagotomy and carotid sinus denervation prevent diuresis following plasma volume expansion in an experimental model?
Does vagotomy and carotid sinus denervation prevent diuresis following plasma volume expansion in an experimental model?
Receptors other than those in the cardiac atria and carotid sinus contribute to the reflex mechanism regulating plasma volume during expansion.
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Animal findings do not guide human volume management; leaves open identification of additional receptors.
J. Pearce (1959) studied this question. Vagotomy and carotid sinus denervation was evaluated on Diuretic and chloruretic response to expansion of plasma volume. Vagotomy and carotid sinus denervation did not prevent the diuretic and chloruretic response to plasma volume expansion, suggesting additional receptors contribute to regulating plasma volume.