Key result
A history of Kawasaki disease with coronary artery aneurysms is associated with increased carotid intima-media thickness, endothelial dysfunction, and arterial stiffness in the longer term.
Why the study?
Do individuals with a history of Kawasaki disease have increased subclinical vascular changes indicative of heightened cardiovascular risk?
Do individuals with a history of Kawasaki disease have increased subclinical vascular changes indicative of heightened cardiovascular risk?
Individuals with a history of Kawasaki disease complicated by coronary artery aneurysms exhibit subclinical vascular changes suggesting heightened cardiovascular risk, highlighting the need to minimize traditional modifiable risk factors.
Suggests need for vigilant risk factor control in Kawasaki survivors; leaves open whether markers predict events.
UNLABELLED: Studies of subclinical vascular changes post-Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima-media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened cardiovascular risk. The results are less consistent for low-risk groups. CONCLUSION: Until data are available from larger prospective studies, it is prudent to advise families of individuals with a history of Kawasaki disease to minimise traditional modifiable cardiovascular risk factors.
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Chen et al. (2016) conducted a review in Kawasaki disease. History of Kawasaki disease with coronary artery aneurysms vs. Low-risk groups was evaluated on Subclinical vascular changes (carotid intima-media thickness, endothelial dysfunction, arterial stiffness). A history of Kawasaki disease with coronary artery aneurysms is associated with increased carotid intima-media thickness, endothelial dysfunction, and arterial stiffness in the longer term.
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