Key result
Parathyroid hormone significantly reduced perfusion defects and enhanced homing of bone marrow-derived stem cells to the ischemic myocardium compared to G-CSF and controls in mice after MI.
Why the study?
Does parathyroid hormone or G-CSF improve myocardial perfusion and stem cell homing after myocardial infarction in mice?
Does parathyroid hormone or G-CSF improve myocardial perfusion and stem cell homing after myocardial infarction in mice?
Parathyroid hormone, unlike G-CSF, enhances stem cell homing and reduces perfusion defects after myocardial infarction in a preclinical mouse model.
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Does not support clinical use after MI; leaves open translation of PTH-enhanced stem cell homing beyond this mouse model.
Hüber et al. (2010) studied Myocardial infarction. Parathyroid hormone (PTH) vs. G-CSF (100 mug/kg) and controls was evaluated on Myocardial perfusion defects and migration of bone marrow-derived stem cells. Parathyroid hormone significantly reduced perfusion defects and enhanced homing of bone marrow-derived stem cells to the ischemic myocardium compared to G-CSF and controls in mice after MI.
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