Key result
Application of antibodies against N-CAM to cultured murine glial precursor cells reduced A-type and delayed rectifier K+ currents, suggesting adhesive events influence the intracellular ionic milieu.
Triggering of N-CAM by antibodies alters K+ channel properties in glial precursor cells, suggesting adhesive events between neural cells can influence the intracellular ionic milieu.
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No immediate clinical implications; leaves open whether N-CAM adhesion modulates glial K+ currents in vivo or humans.
Sontheimer et al. (1991) studied this question. Antibodies against the neural cell adhesion molecule (N-CAM) vs. Antibodies against O4 surface antigen or liver cell membranes was evaluated on A-type and delayed rectifier K+ currents amplitude. Application of antibodies against N-CAM to cultured murine glial precursor cells reduced A-type and delayed rectifier K+ currents, suggesting adhesive events influence the intracellular ionic milieu.
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